Journal article
Merozoite antigens of plasmodium falciparum elicit strain-transcending opsonizing immunity
DL Hill, DW Wilson, NG Sampaio, EM Eriksson, V Ryg-Cornejo, GL Abby Harrison, AD Uboldi, LJ Robinson, JG Beeson, P Siba, AF Cowman, DS Hansen, I Mueller, L Schofielda
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2016
DOI: 10.1128/IAI.00145-16
Abstract
It is unclear whether naturally acquired immunity to Plasmodium falciparum results from the acquisition of antibodies to multiple, diverse antigens or to fewer, highly conserved antigens. Moreover, the specific antibody functions required for malaria immunity are unknown, and hence informative immunological assays are urgently needed to address these knowledge gaps and guide vaccine development. In this study, we investigated whether merozoite-opsonizing antibodies are associated with protection from malaria in a strain-specific or strain-transcending manner by using a novel field isolate and an immune plasmamatched cohort from Papua New Guinea with our validated assay of merozoite phagocyto..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work, including the efforts of Danika L. Hill, Danny W. Wilson, Natalia G. Sampaio, Emily M. Eriksson, Victoria Ryg-Cornejo, G. L. Abby Harrison, Alessandro D. Uboldi, Leanne J. Robinson, James G. Beeson, Peter Siba, Alan F. Cowman, Diana S. Hansen, Ivo Mueller, and Louis Schofield, was funded by Department of Health | National Health and Medical Research Council (NHMRC) (1031212, 106722, and 637406).